E3 ubiquitin-protein ligase RNFT2 (RNFT2)

About E3 ubiquitin-protein ligase RNFT2

E3 ubiquitin-protein ligase RNFT2 (RNFT2) is a protein from Homo sapiens identified by UniProt accession Q96EX2, 444 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNFT2
UniProt accession	Q96EX2
Gene	RNFT2
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

protein measurement · score 0.22
neuroticism measurement · score 0.18
high density lipoprotein cholesterol measurement · score 0.14
apolipoprotein A 1 measurement · score 0.14
hippocampal volume · score 0.12
gut microbiome measurement · score 0.11
worry measurement · score 0.11
brain volume measurement · score 0.10
eosinophil count · score 0.08
neuronal ceroid lipofuscinosis 1 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EX2-F1	alphafold	PREDICTED	70.20	—

Amino-acid sequence (444 residues)

MWLFTVNQVL RKMQRRHSSN TDNIPPERNR SQALSSEASV DEGGVFESLK AEAASPPALF SGLSGSLPTS SFPSSLVLGS SAGGGDVFIQ MPASREEGGG RGEGGAYHHR QPHHHFHHGG HRGGSLLQHV GGDHRGHSEE GGDEQPGTPA PALSELKAVI CWLQKGLPFI LILLAKLCFQ HKLGIAVCIG MASTFAYANS TLREQVSLKE KRSVLVILWI LAFLAGNTLY VLYTFSSQQL YNSLIFLKPN LEMLDFFDLL WIVGIADFVL KYITIALKCL IVALPKIILA VKSKGKFYLV IEELSQLFRS LVPIQLWYKY IMGDDSSNSY FLGGVLIVLY SLCKSFDICG RVGGVRKALK LLCTSQNYGV RATGQQCTEA GDICAICQAE FREPLILLCQ HVFCEECLCL WLDRERTCPL CRSVAVDTLR CWKDGATSAH FQVY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards