About Cytoplasmic dynein 2 intermediate chain 2
Cytoplasmic dynein 2 intermediate chain 2 (DYNC2I2) is a protein
from Homo sapiens identified by UniProt accession
Q96EX3, 536 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Cytoplasmic dynein 2 intermediate chain 2 |
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| UniProt accession | Q96EX3 |
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| Gene | DYNC2I2 |
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| Organism | Homo sapiens |
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| Length | 536 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- Short rib-polydactyly syndrome, Verma-Naumoff type · score 0.78
- Jeune syndrome · score 0.58
- asphyxiating thoracic dystrophy 3 · score 0.42
- short rib-polydactyly syndrome, Majewski type · score 0.42
- genetic disorder · score 0.19
- Meckel syndrome · score 0.04
- ulnar hemimelia · score 0.04
- Acropectorovertebral dysplasia · score 0.03
- Humero-radial synostosis · score 0.03
- hepatocellular carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96EX3-F1 | alphafold | PREDICTED | 82.09 | — |
Amino-acid sequence (536 residues)
MATRAQPGPL SQAGSAGVAA LATVGVASGP GPGRPGPLQD ETLGVASVPS QWRAVQGIRW ETKSCQTASI ATASASAQAR NHVDAQVQTE APVPVSVQPP SQYDIPRLAA FLRRVEAMVI RELNKNWQSH AFDGFEVNWT EQQQMVSCLY TLGYPPAQAQ GLHVTSISWN STGSVVACAY GRLDHGDWST LKSFVCAWNL DRRDLRPQQP SAVVEVPSAV LCLAFHPTQP SHVAGGLYSG EVLVWDLSRL EDPLLWRTGL TDDTHTDPVS QVVWLPEPGH SHRFQVLSVA TDGKVLLWQG IGVGQLQLTE GFALVMQQLP RSTKLKKHPR GETEVGATAV AFSSFDPRLF ILGTEGGFPL KCSLAAGEAA LTRMPSSVPL RAPAQFTFSP HGGPIYSVSC SPFHRNLFLS AGTDGHVHLY SMLQAPPLTS LQLSLKYLFA VRWSPVRPLV FAAASGKGDV QLFDLQKSSQ KPTVLIKQTQ DESPVYCLEF NSQQTQLLAA GDAQGTVKVW QLSTEFTEQG PREAEDLDCL AAEVAA
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