Corrinoid adenosyltransferase MMAB (MMAB)

About Corrinoid adenosyltransferase MMAB

Corrinoid adenosyltransferase MMAB (MMAB) is a protein from Homo sapiens identified by UniProt accession Q96EY8, 250 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Corrinoid adenosyltransferase MMAB
UniProt accession	Q96EY8
Gene	MMAB
Organism	Homo sapiens
Length	250 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (142)

Diseases linked to this target (Open Targets).

methylmalonic aciduria, cblB type · score 0.81
Vitamin B12-responsive methylmalonic acidemia type cblB · score 0.80
methylmalonic acidemia · score 0.55
genetic disorder · score 0.49
neurodegenerative disease · score 0.48
high density lipoprotein cholesterol measurement · score 0.41
mean platelet volume · score 0.35
disseminated superficial actinic porokeratosis · score 0.33
apolipoprotein A 1 measurement · score 0.30
body mass index · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EY8-F1	alphafold	PREDICTED	81.72	—

Amino-acid sequence (250 residues)

MAVCGLGSRL GLGSRLGLRG CFGAARLLYP RFQSRGPQGV EDGDRPQPSS KTPRIPKIYT KTGDKGFSST FTGERRPKDD QVFEAVGTTD ELSSAIGFAL ELVTEKGHTF AEELQKIQCT LQDVGSALAT PCSSAREAHL KYTTFKAGPI LELEQWIDKY TSQLPPLTAF ILPSGGKISS ALHFCRAVCR RAERRVVPLV QMGETDANVA KFLNRLSDYL FTLARYAAMK EGNQEKIYMK NDPSAESEGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards