Nuclear receptor-binding factor 2 (NRBF2)

About Nuclear receptor-binding factor 2

Nuclear receptor-binding factor 2 (NRBF2) is a protein from Homo sapiens identified by UniProt accession Q96F24, 287 residues long. MolForge cross-references it against 0 known binders and 169 disease associations.

Target properties

Protein name	Nuclear receptor-binding factor 2
UniProt accession	Q96F24
Gene	NRBF2
Organism	Homo sapiens
Length	287 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (169)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
sex hormone-binding globulin measurement · score 0.44
mean platelet volume · score 0.42
testosterone measurement · score 0.42
mean corpuscular volume · score 0.42
platelet count · score 0.42
mean corpuscular hemoglobin · score 0.39
triglyceride measurement · score 0.36
lysosomal storage disease · score 0.36
diet measurement · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96F24-F1	alphafold	PREDICTED	72.89	—

Amino-acid sequence (287 residues)

MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS EQAHLSLELQ RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT SHKPSAEDAE GQSPLSQKYS PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE PAEPCIGSKA PKDDKTIIEE QATKIADLKR HVEFLVAENE RLRKENKQLK AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS STWQKFAANT GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards