E3 ubiquitin-protein ligase TRIM11 (TRIM11)

About E3 ubiquitin-protein ligase TRIM11

E3 ubiquitin-protein ligase TRIM11 (TRIM11) is a protein from Homo sapiens identified by UniProt accession Q96F44, 468 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM11
UniProt accession	Q96F44
Gene	TRIM11
Organism	Homo sapiens
Length	468 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

clear cell renal carcinoma · score 0.18
hepatocellular carcinoma · score 0.09
gonorrhea · score 0.09
calf circumference measurement · score 0.08
non-small cell lung carcinoma · score 0.08
Chordoma · score 0.08
osteosarcoma · score 0.07
prostate cancer · score 0.07
neoplasm · score 0.07
Ehlers-Danlos syndrome, musculocontractural type · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96F44-F1	alphafold	PREDICTED	88.57	—

Amino-acid sequence (468 residues)

MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECRELS PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA AFCGDELRLL CAACERSGEH WAHRVRPLQD AAEDLKAKLE KSLEHLRKQM QDALLFQAQA DETCVLWQKM VESQRQNVLG EFERLRRLLA EEEQQLLQRL EEEELEVLPR LREGAAHLGQ QSAHLAELIA ELEGRCQLPA LGLLQDIKDA LRRVQDVKLQ PPEVVPMELR TVCRVPGLVE TLRRFRGDVT LDPDTANPEL ILSEDRRSVQ RGDLRQALPD SPERFDPGPC VLGQERFTSG RHYWEVEVGD RTSWALGVCR ENVNRKEKGE LSAGNGFWIL VFLGSYYNSS ERALAPLRDP PRRVGIFLDY EAGHLSFYSA TDGSLLFIFP EIPFSGTLRP LFSPLSSSPT PMTICRPKGG SGDTLAPQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards