E3 ubiquitin-protein ligase pellino homolog 1 (PELI1)

About E3 ubiquitin-protein ligase pellino homolog 1

E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) is a protein from Homo sapiens identified by UniProt accession Q96FA3, 418 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase pellino homolog 1
UniProt accession	Q96FA3
Gene	PELI1
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

neuroticism measurement · score 0.32
body height · score 0.25
mathematical ability · score 0.23
self reported educational attainment · score 0.23
intelligence · score 0.14
drug use measurement · score 0.13
neoplasm · score 0.10
breast adenocarcinoma · score 0.10
Sepsis · score 0.09
Systemic lupus erythematosus · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FA3-F1	alphafold	PREDICTED	89.52	—

Amino-acid sequence (418 residues)

MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG SQSNSDTQSV QSTISRFACR IICERNPPFT ARIYAAGFDS SKNIFLGEKA AKWKTSDGQM DGLTTNGVLV MHPRNGFTED SKPGIWREIS VCGNVFSLRE TRSAQQRGKM VEIETNQLQD GSLIDLCGAT LLWRTAEGLS HTPTVKHLEA LRQEINAARP QCPVGFNTLA FPSMKRKDVV DEKQPWVYLN CGHVHGYHNW GNKEERDGKD RECPMCRSVG PYVPLWLGCE AGFYVDAGPP THAFSPCGHV CSEKTTAYWS QIPLPHGTHT FHAACPFCAH QLAGEQGYIR LIFQGPLD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards