Methyltransferase-like protein 25B (METTL25B)

About Methyltransferase-like protein 25B

Methyltransferase-like protein 25B (METTL25B) is a protein from Homo sapiens identified by UniProt accession Q96FB5, 475 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Methyltransferase-like protein 25B
UniProt accession	Q96FB5
Gene	METTL25B
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.25
sex hormone-binding globulin measurement · score 0.20
total blood protein measurement · score 0.18
bilirubin measurement · score 0.17
Red cell distribution width · score 0.17
blood protein measurement · score 0.11
platelet count · score 0.09
platelet crit · score 0.08
body height · score 0.04
lymphocyte count · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FB5-F1	alphafold	PREDICTED	91.29	—

Amino-acid sequence (475 residues)

MPGISARGLS HEGRKQLAVN LTRVLALYRS ILDAYIIEFF TDNLWDTLPC SWQEALDGLK PPQLATMLLG MPGEGEVVRY RSVWPLTLLA LKSTACALAF TRMPGFQTPS EFLENPSQSS RLTAPFRKHV RPKKQHEIRR LGELVKKLSD FTGCTQVVDV GSGQGHLSRF MALGLGLMVK SIEGDQRLVE RAQRLDQELL QALEKEEKRN PQVVQTSPRH SPHHVVRWVD PTALCEELLL PLENPCQGRA RLLLTGLHAC GDLSVALLRH FSCCPEVVAL ASVGCCYMKL SDPGGYPLSQ WVAGLPGYEL PYRLREGACH ALEEYAERLQ KAGPGLRTHC YRAALETVIR RARPELRRPG VQGIPRVHEL KIEEYVQRGL QRVGLDPQLP LNLAALQAHV AQENRVVAFF SLALLLAPLV ETLILLDRLL YLQEQGFHAE LLPIFSPELS PRNLVLVATK MPLGQALSVL ETEDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards