About Phytanoyl-CoA hydroxylase-interacting protein-like
Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL) is a protein
from Homo sapiens identified by UniProt accession
Q96FC7, 376 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Phytanoyl-CoA hydroxylase-interacting protein-like |
|---|
| UniProt accession | Q96FC7 |
|---|
| Gene | PHYHIPL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 376 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- DNA methylation · score 0.20
- metabolite measurement · score 0.08
- chronotype measurement · score 0.07
- hypertension · score 0.05
- diastolic blood pressure · score 0.05
- vital capacity · score 0.05
- Crohn's disease · score 0.04
- colorectal adenocarcinoma · score 0.03
- hepatocellular carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96FC7-F1 | alphafold | PREDICTED | 82.59 | — |
Amino-acid sequence (376 residues)
MEVPRLDHAL NSPTSPCEEV IKNLSLEAIQ LCDRDGNKSQ DSGIAEMEEL PVPHNIKISN ITCDSFKISW EMDSKSKDRI THYFIDLNKK ENKNSNKFKH KDVPTKLVAK AVPLPMTVRG HWFLSPRTEY TVAVQTASKQ VDGDYVVSEW SEIIEFCTAD YSKVHLTQLL EKAEVIAGRM LKFSVFYRNQ HKEYFDYVRE HHGNAMQPSV KDNSGSHGSP ISGKLEGIFF SCSTEFNTGK PPQDSPYGRY RFEIAAEKLF NPNTNLYFGD FYCMYTAYHY VILVIAPVGS PGDEFCKQRL PQLNSKDNKF LTCTEEDGVL VYHHAQDVIL EVIYTDPVDL SVGTVAEITG HQLMSLSTAN AKKDPSCKTC NISVGR
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