About Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) is a protein
from Homo sapiens identified by UniProt accession
Q96FE5, 620 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 |
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| UniProt accession | Q96FE5 |
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| Gene | LINGO1 |
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| Organism | Homo sapiens |
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| Length | 620 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (122)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal recessive 64 · score 0.62
- self reported educational attainment · score 0.51
- neuroticism measurement · score 0.50
- body mass index · score 0.50
- body fat percentage · score 0.47
- body weight · score 0.45
- wellbeing measurement · score 0.45
- depressive symptom measurement · score 0.44
- lean body mass · score 0.44
- smoking status measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96FE5-F1 | alphafold | PREDICTED | 86.13 | — |
Amino-acid sequence (620 residues)
MQVSKRMLAG GVRSMPSPLL ACWQPILLLV LGSVLSGSAT GCPPRCECSA QDRAVLCHRK RFVAVPEGIP TETRLLDLGK NRIKTLNQDE FASFPHLEEL ELNENIVSAV EPGAFNNLFN LRTLGLRSNR LKLIPLGVFT GLSNLTKLDI SENKIVILLD YMFQDLYNLK SLEVGDNDLV YISHRAFSGL NSLEQLTLEK CNLTSIPTEA LSHLHGLIVL RLRHLNINAI RDYSFKRLYR LKVLEISHWP YLDTMTPNCL YGLNLTSLSI THCNLTAVPY LAVRHLVYLR FLNLSYNPIS TIEGSMLHEL LRLQEIQLVG GQLAVVEPYA FRGLNYLRVL NVSGNQLTTL EESVFHSVGN LETLILDSNP LACDCRLLWV FRRRWRLNFN RQQPTCATPE FVQGKEFKDF PDVLLPNYFT CRRARIRDRK AQQVFVDEGH TVQFVCRADG DPPPAILWLS PRKHLVSAKS NGRLTVFPDG TLEVRYAQVQ DNGTYLCIAA NAGGNDSMPA HLHVRSYSPD WPHQPNKTFA FISNQPGEGE ANSTRATVPF PFDIKTLIIA TTMGFISFLG VVLFCLVLLF LWSRGKGNTK HNIEIEYVPR KSDAGISSAD APRKFNMKMI
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