Endonuclease 8-like 1 (NEIL1)

About Endonuclease 8-like 1

Endonuclease 8-like 1 (NEIL1) is a protein from Homo sapiens identified by UniProt accession Q96FI4, 390 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.

Target properties

Protein name	Endonuclease 8-like 1
UniProt accession	Q96FI4
Gene	NEIL1
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (171)

Diseases linked to this target (Open Targets).

cancer · score 0.56
breast adenocarcinoma · score 0.18
platelet count · score 0.14
mean platelet volume · score 0.12
type 2 diabetes mellitus · score 0.10
glomerular filtration rate · score 0.09
urate measurement · score 0.08
creatinine measurement · score 0.08
MODY · score 0.07
cystatin C measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FI4-F1	alphafold	PREDICTED	80.51	—

Amino-acid sequence (390 residues)

MPEGPELHLA SQFVNEACRA LVFGGCVEKS SVSRNPEVPF ESSAYRISAS ARGKELRLIL SPLPGAQPQQ EPLALVFRFG MSGSFQLVPR EELPRHAHLR FYTAPPGPRL ALCFVDIRRF GRWDLGGKWQ PGRGPCVLQE YQQFRENVLR NLADKAFDRP ICEALLDQRF FNGIGNYLRA EILYRLKIPP FEKARSVLEA LQQHRPSPEL TLSQKIRTKL QNPDLLELCH SVPKEVVQLG GKGYGSESGE EDFAAFRAWL RCYGMPGMSS LQDRHGRTIW FQGDPGPLAP KGRKSRKKKS KATQLSPEDR VEDALPPSKA PSRTRRAKRD LPKRTATQRP EGTSLQQDPE APTVPKKGRR KGRQAASGHC RPRKVKADIP SLEPEGTSAS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards