AMSH-like protease (STAMBPL1)

About AMSH-like protease

AMSH-like protease (STAMBPL1) is a protein from Homo sapiens identified by UniProt accession Q96FJ0, 436 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	AMSH-like protease
UniProt accession	Q96FJ0
Gene	STAMBPL1
Organism	Homo sapiens
Length	436 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

aortic aneurysm, familial thoracic 6 · score 0.57
familial thoracic aortic aneurysm and aortic dissection · score 0.56
Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.56
multisystemic smooth muscle dysfunction syndrome · score 0.53
Moyamoya disease 5 · score 0.51
Familial hemophagocytic lymphohistiocytosis · score 0.41
connective tissue disease · score 0.36
neurodegenerative disease · score 0.34
Descending aortic dissection · score 0.34
thoracic aortic aneurysm · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FJ0-F1	alphafold	PREDICTED	83.10	—

Amino-acid sequence (436 residues)

MDQPFTVNSL KKLAAMPDHT DVSLSPEERV RALSKLGCNI TISEDITPRR YFRSGVEMER MASVYLEEGN LENAFVLYNK FITLFVEKLP NHRDYQQCAV PEKQDIMKKL KEIAFPRTDE LKNDLLKKYN VEYQEYLQSK NKYKAEILKK LEHQRLIEAE RKRIAQMRQQ QLESEQFLFF EDQLKKQELA RGQMRSQQTS GLSEQIDGSA LSCFSTHQNN SLLNVFADQP NKSDATNYAS HSPPVNRALT PAATLSAVQN LVVEGLRCVV LPEDLCHKFL QLAESNTVRG IETCGILCGK LTHNEFTITH VIVPKQSAGP DYCDMENVEE LFNVQDQHDL LTLGWIHTHP TQTAFLSSVD LHTHCSYQLM LPEAIAIVCS PKHKDTGIFR LTNAGMLEVS ACKKKGFHPH TKEPRLFSIC KHVLVKDIKI IVLDLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards