GPI-specific phospholipase A2-like PGAP3 (PGAP3)

About GPI-specific phospholipase A2-like PGAP3

GPI-specific phospholipase A2-like PGAP3 (PGAP3) is a protein from Homo sapiens identified by UniProt accession Q96FM1, 320 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.

Target properties

Protein name	GPI-specific phospholipase A2-like PGAP3
UniProt accession	Q96FM1
Gene	PGAP3
Organism	Homo sapiens
Length	320 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (101)

Diseases linked to this target (Open Targets).

hyperphosphatasia-intellectual disability syndrome · score 0.70
genetic disorder · score 0.47
Global developmental delay · score 0.34
Seizure · score 0.34
Cleft palate · score 0.34
Low posterior hairline · score 0.34
congenital diaphragmatic hernia · score 0.34
Low-set ears · score 0.34
Agenesis of maxillary lateral incisor · score 0.34
Severe global developmental delay · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FM1-F1	alphafold	PREDICTED	92.61	—

Amino-acid sequence (320 residues)

MAGLAARLVL LAGAAALASG SQGDREPVYR DCVLQCEEQN CSGGALNHFR SRQPIYMSLA GWTCRDDCKY ECMWVTVGLY LQEGHKVPQF HGKWPFSRFL FFQEPASAVA SFLNGLASLV MLCRYRTFVP ASSPMYHTCV AFAWVSLNAW FWSTVFHTRD TDLTEKMDYF CASTVILHSI YLCCVRTVGL QHPAVVSAFR ALLLLMLTVH VSYLSLIRFD YGYNLVANVA IGLVNVVWWL AWCLWNQRRL PHVRKCVVVV LLLQGLSLLE LLDFPPLFWV LDAHAIWHIS TIPVHVLFFS FLEDDSLYLL KESEDKFKLD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards