Copine-2 (CPNE2)

About Copine-2

Copine-2 (CPNE2) is a protein from Homo sapiens identified by UniProt accession Q96FN4, 548 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Copine-2
UniProt accession	Q96FN4
Gene	CPNE2
Organism	Homo sapiens
Length	548 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.15
neurodegenerative disease · score 0.11
lymphocyte count · score 0.08
metabolite measurement · score 0.07
lymphocyte percentage of leukocytes · score 0.07
eosinophil percentage of leukocytes · score 0.07
breast milk measurement · score 0.05
neutrophil percentage of leukocytes · score 0.05
multiple sclerosis · score 0.05
mean corpuscular hemoglobin concentration · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FN4-F1	alphafold	PREDICTED	91.09	—

Amino-acid sequence (548 residues)

MAHIPSGGAP AAGAAPMGPQ YCVCKVELSV SGQNLLDRDV TSKSDPFCVL FTENNGRWIE YDRTETAINN LNPAFSKKFV LDYHFEEVQK LKFALFDQDK SSMRLDEHDF LGQFSCSLGT IVSSKKITRP LLLLNDKPAG KGLITIAAQE LSDNRVITLS LAGRRLDKKD LFGKSDPFLE FYKPGDDGKW MLVHRTEVIK YTLDPVWKPF TVPLVSLCDG DMEKPIQVMC YDYDNDGGHD FIGEFQTSVS QMCEARDSVP LEFECINPKK QRKKKNYKNS GIIILRSCKI NRDYSFLDYI LGGCQLMFTV GIDFTASNGN PLDPSSLHYI NPMGTNEYLS AIWAVGQIIQ DYDSDKMFPA LGFGAQLPPD WKVSHEFAIN FNPTNPFCSG VDGIAQAYSA CLPHIRFYGP TNFSPIVNHV ARFAAQATQQ RTATQYFILL IITDGVISDM EETRHAVVQA SKLPMSIIIV GVGNADFAAM EFLDGDSRML RSHTGEEAAR DIVQFVPFRE FRNAAKETLA KAVLAELPQQ VVQYFKHKNL PPTNSEPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards