Acid-sensing ion channel 4 (ASIC4)

About Acid-sensing ion channel 4

Acid-sensing ion channel 4 (ASIC4) is a protein from Homo sapiens identified by UniProt accession Q96FT7, 539 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Acid-sensing ion channel 4
UniProt accession	Q96FT7
Gene	ASIC4
Organism	Homo sapiens
Length	539 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
vital capacity · score 0.29
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.16
cortical thickness · score 0.12
head and neck squamous cell carcinoma · score 0.12
glomerular filtration rate · score 0.08
cognitive function measurement · score 0.07
creatinine measurement · score 0.07
body height · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FT7-F1	alphafold	PREDICTED	79.69	—

Amino-acid sequence (539 residues)

MPIEIVCKIK FAEEDAKPKE KEAGDEQSLL GAVAPGAAPR DLATFASTST LHGLGRACGP GPHGLRRTLW ALALLTSLAA FLYQAAGLAR GYLTRPHLVA MDPAAPAPVA GFPAVTLCNI NRFRHSALSD ADIFHLANLT GLPPKDRDGH RAAGLRYPEP DMVDILNRTG HQLADMLKSC NFSGHHCSAS NFSVVYTRYG KCYTFNADPR SSLPSRAGGM GSGLEIMLDI QQEEYLPIWR ETNETSFEAG IRVQIHSQEE PPYIHQLGFG VSPGFQTFVS CQEQRLTYLP QPWGNCRAES ELREPELQGY SAYSVSACRL RCEKEAVLQR CHCRMVHMPG NETICPPNIY IECADHTLDS LGGGPEGPCF CPTPCNLTRY GKEISMVRIP NRGSARYLAR KYNRNETYIR ENFLVLDVFF EALTSEAMEQ RAAYGLSALL GDLGGQMGLF IGASILTLLE ILDYIYEVSW DRLKRVWRRP KTPLRTSTGG ISTLGLQELK EQSPCPSRGR VEGGGVSSLL PNHHHPHGPP GGLFEDFAC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards