About Intraflagellar transport protein 43 homolog
Intraflagellar transport protein 43 homolog (IFT43) is a protein
from Homo sapiens identified by UniProt accession
Q96FT9, 208 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Intraflagellar transport protein 43 homolog |
|---|
| UniProt accession | Q96FT9 |
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| Gene | IFT43 |
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| Organism | Homo sapiens |
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| Length | 208 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (94)
Diseases linked to this target (Open Targets).
- cranioectodermal dysplasia · score 0.71
- short rib dysplasia · score 0.67
- retinitis pigmentosa · score 0.34
- short rib-polydactyly syndrome · score 0.33
- body height · score 0.31
- IGF-1 measurement · score 0.24
- mean platelet volume · score 0.23
- appendicular lean mass · score 0.19
- Polydactyly · score 0.18
- polydactyly · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96FT9-F1 | alphafold | PREDICTED | 63.26 | — |
Amino-acid sequence (208 residues)
MEDLLDLDEE LRYSLATSRA KMGRRAQQES AQAENHLNGK NSSLTLTGET SSAKLPRCRQ GGWAGDSVKA SKFRRKASEE IEDFRLRPQS LNGSDYGGDI PIIPDLEEVQ EEDFVLQVAA PPSIQIKRVM TYRDLDNDLM KYSAIQTLDG EIDLKLLTKV LAPEHEVRED DVGWDWDHLF TEVSSEVLTE WDPLQTEKED PAGQARHT
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