Leucine-rich repeat-containing protein 46 (LRRC46)

About Leucine-rich repeat-containing protein 46

Leucine-rich repeat-containing protein 46 (LRRC46) is a protein from Homo sapiens identified by UniProt accession Q96FV0, 321 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 46
UniProt accession	Q96FV0
Gene	LRRC46
Organism	Homo sapiens
Length	321 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

hair color · score 0.18
prostate carcinoma · score 0.16
body fat distribution · score 0.16
type 2 diabetes mellitus · score 0.13
balding measurement · score 0.12
drug use measurement · score 0.12
azoospermia · score 0.10
pulse pressure measurement · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FV0-F1	alphafold	PREDICTED	63.91	—

Amino-acid sequence (321 residues)

MSGGKSAQGP EEGGVCITEA LITKRNLTFP EDGELSEKMF HTLDELQTVR LDREGITTIR NLEGLQNLHS LYLQGNKIQQ IENLACIPSL RFLSLAGNQI RQVENLLDLP CLQFLDLSEN LIETLKLDEF PQSLLILNLS GNSCTNQDGY RELVTEALPL LLDLDGQPVV ERWISDEEDE ASSDEEFPEL SGPFCSERGF LKELEQELSR HREHRQQTAL TEHLLRMEMQ PTLTDLPLLP GVPMAGDSSP SATPAQGEET VPEAVSSPQA SSPTKKPCSL IPRGHQSSFW GRKGARAATA PKASVAEAPS TTKTTAKRSK K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards