About Tetraspanin-17
Tetraspanin-17 (TSPAN17) is a protein
from Homo sapiens identified by UniProt accession
Q96FV3, 270 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Tetraspanin-17 |
|---|
| UniProt accession | Q96FV3 |
|---|
| Gene | TSPAN17 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 270 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.08
- hypertriglyceridemia 2 · score 0.06
- cholesterol-ester transfer protein deficiency · score 0.06
- hemochromatosis type 5 · score 0.05
- FTH1-related iron overload · score 0.05
- Combined hyperlipidemia · score 0.05
- thyroid hormone metabolism, abnormal, 2 · score 0.04
- sitosterolemia · score 0.04
- homozygous familial hypercholesterolemia · score 0.04
- hypercholesterolemia, autosomal dominant, 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96FV3-F1 | alphafold | PREDICTED | 88.36 | — |
Amino-acid sequence (270 residues)
MPGKHQHFQE PEVGCCGKYF LFGFNIVFWV LGALFLAIGL WAWGEKGVLS NISALTDLGG LDPVWLFVVV GGVMSVLGFA GCIGALRENT FLLKFFSVFL GLIFFLELAT GILAFVFKDW IRDQLNLFIN NNVKAYRDDI DLQNLIDFAQ EYWSCCGARG PNDWNLNIYF NCTDLNPSRE RCGVPFSCCV RDPAEDVLNT QCGYDVRLKL ELEQQGFIHT KGCVGQFEKW LQDNLIVVAG VFMGIALLQI FGICLAQNLV SDIKAVKANW
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