About Ubiquitin thioesterase OTUB1
Ubiquitin thioesterase OTUB1 (OTUB1) is a protein
from Homo sapiens identified by UniProt accession
Q96FW1, 271 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | Ubiquitin thioesterase OTUB1 |
|---|
| UniProt accession | Q96FW1 |
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| Gene | OTUB1 |
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| Organism | Homo sapiens |
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| Length | 271 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (125)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- breast adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.20
- squamous cell lung carcinoma · score 0.19
- endometrial cancer · score 0.18
- prostate adenocarcinoma · score 0.12
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.08
- Miyoshi myopathy · score 0.08
- renal cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96FW1-F1 | alphafold | PREDICTED | 91.74 | — |
Amino-acid sequence (271 residues)
MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K
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