Diphthamide biosynthesis protein 3 (DPH3)

About Diphthamide biosynthesis protein 3

Diphthamide biosynthesis protein 3 (DPH3) is a protein from Homo sapiens identified by UniProt accession Q96FX2, 82 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Diphthamide biosynthesis protein 3
UniProt accession	Q96FX2
Gene	DPH3
Organism	Homo sapiens
Length	82 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

melanoma · score 0.09
diffuse plaque measurement · score 0.05
neoplasm · score 0.05
skin basal cell carcinoma · score 0.03
protein measurement · score 0.03
squamous cell carcinoma · score 0.01
psoriasis · score 0.01
cancer · score 0.01
ovarian carcinoma · score 0.01
pancreatic ductal adenocarcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FX2-F1	alphafold	PREDICTED	83.60	—

Amino-acid sequence (82 residues)

MAVFHDEVEI EDFQYDEDSE TYFYPCPCGD NFSITKEDLE NGEDVATCPS CSLIIKVIYD KDQFVCGETV PAPSANKELV KC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards