CKLF-like MARVEL transmembrane domain-containing…

About CKLF-like MARVEL transmembrane domain-containing protein 7

CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) is a protein from Homo sapiens identified by UniProt accession Q96FZ5, 175 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	CKLF-like MARVEL transmembrane domain-containing protein 7
UniProt accession	Q96FZ5
Gene	CMTM7
Organism	Homo sapiens
Length	175 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

serum IgM measurement · score 0.31
adolescent idiopathic scoliosis · score 0.30
eosinophil count · score 0.28
neurofibrillary tangles measurement · score 0.26
total cholesterol measurement · score 0.11
low density lipoprotein cholesterol measurement · score 0.10
drug use measurement · score 0.10
isolated asymptomatic elevation of creatine phosphokinase · score 0.07
non-small cell lung carcinoma · score 0.06
body height · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FZ5-F1	alphafold	PREDICTED	69.55	—

Amino-acid sequence (175 residues)

MSHGAGLVRT TCSSGSALGP GAGAAQPSAS PLEGLLDLSY PRTHAALLKV AQMVTLLIAF ICVRSSLWTN YSAYSYFEVV TICDLIMILA FYLVHLFRFY RVLTCISWPL SELLHYLIGT LLLLIASIVA ASKSYNQSGL VAGAIFGFMA TFLCMASIWL SYKISCVTQS TDAAV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7)