Protein-lysine N-methyltransferase EEF2KMT (EEF2KMT)

About Protein-lysine N-methyltransferase EEF2KMT

Protein-lysine N-methyltransferase EEF2KMT (EEF2KMT) is a protein from Homo sapiens identified by UniProt accession Q96G04, 330 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Protein-lysine N-methyltransferase EEF2KMT
UniProt accession	Q96G04
Gene	EEF2KMT
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

congenital disorder of glycosylation · score 0.48
ALG1-congenital disorder of glycosylation · score 0.46
genetic disorder · score 0.32
MODY · score 0.08
diabetes mellitus, transient neonatal, 2 · score 0.05
butyrylcholinesterase deficiency · score 0.04
small vessel stroke · score 0.02
mean corpuscular volume · score 0.02
lung adenocarcinoma · score 0.02
cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96G04-F1	alphafold	PREDICTED	92.28	—

Amino-acid sequence (330 residues)

MAPEENAGTE LLLQSFERRF LAARTLRSFP WQSLEAKLRD SSDSELLRDI LHKTVKHPVC VKHPPSVKYA RCFLSELIKK HEAVHTEPLD ELYEALAETL MAKESTQGHR SYLLPSGGSV TLSESTAIIS YGTTGLVTWD AALYLAEWAI ENPAVFTNRT VLELGSGAGL TGLAICKMCR PRAYIFSDCH SRVLEQLRGN VLLNGLSLEA DITAKLDSPR VTVAQLDWDV ATVHQLSAFQ PDVVIAADVL YCPEAIMSLV GVLRRLAACR EHQRAPEVYV AFTVRNPETC QLFTTELGRA GIRWEVEPRH EQKLFPYEEH LEMAMLNLTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards