About Kelch domain-containing protein 7B
Kelch domain-containing protein 7B (KLHDC7B) is a protein
from Homo sapiens identified by UniProt accession
Q96G42, 594 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Kelch domain-containing protein 7B |
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| UniProt accession | Q96G42 |
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| Gene | KLHDC7B |
|---|
| Organism | Homo sapiens |
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| Length | 594 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (61)
Diseases linked to this target (Open Targets).
- hearing loss · score 0.59
- hearing measurement · score 0.56
- age-related hearing impairment · score 0.32
- neurodegenerative disease · score 0.32
- diet measurement · score 0.26
- monocyte count · score 0.25
- mean corpuscular volume · score 0.19
- erythrocyte count · score 0.10
- mean corpuscular hemoglobin concentration · score 0.10
- monocyte percentage of leukocytes · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96G42-F1 | alphafold | PREDICTED | 69.00 | — |
Amino-acid sequence (594 residues)
MVLRSHPFPR QDRPQGSVPR AVPGSPVGPS TSTHSEDRHG PSSSVGTVIG TGTGGLVEAG GQPQPRSSET NGSPSPDPPP GLRGEGTREK SLDPLPQAAM PRGPAQPPAQ RPPGPAASSS ARRSQPVPQL RKRSRCEIAP SSEQEVRPAA SGDPQGEAPG EGGSPAGRSG ALTEKQEEAR KLMVFLQRPG GWGVVEGPRK PSSRALEPAT AAALRRRLDL GSCLDVLAFA QQHGEPGLAQ ETYALMSDNL LRVLGDPCLY RRLSAADRER ILSLRTGRGR AVLGVLVLPS LYQGGRSGLP RGPRGEEPPA AAPVSLPLPA HLHVFNPREN TWRPLTQVPE EAPLRGCGLC TMHNYLFLAG GIRGSGAKAV CSNEVFCYNP LTNIWSQVRP MQQARAQLKL VALDGLLYAI GGECLYSMEC YDPRTDAWTP RAPLPAGTFP VAHEAVACRG DIYVTGGHLF YRLLRYSPVK DAWDECPYSA SHRRSSDIVA LGGFLYRFDL LRGVGAAVMR YNTVTGSWSR AASLPLPAPA PLHCTTLGNT IYCLNPQVTA TFTVSGGTAQ FQAKELQPFP LGSTGVLSPF ILTLPPEDRL QTSL
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