About OTU domain-containing protein 5
OTU domain-containing protein 5 (OTUD5) is a protein
from Homo sapiens identified by UniProt accession
Q96G74, 571 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | OTU domain-containing protein 5 |
|---|
| UniProt accession | Q96G74 |
|---|
| Gene | OTUD5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 571 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- multiple congenital anomalies-neurodevelopmental syndrome, X-linked · score 0.69
- Neurodevelopmental disorder · score 0.37
- complex neurodevelopmental disorder · score 0.37
- genetic disorder · score 0.34
- neurodegeneration with brain iron accumulation 5 · score 0.26
- glioblastoma multiforme · score 0.23
- breast adenocarcinoma · score 0.23
- lung adenocarcinoma · score 0.19
- squamous cell lung carcinoma · score 0.19
- gastric adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96G74-F1 | alphafold | PREDICTED | 63.71 | — |
Amino-acid sequence (571 residues)
MTILPKKKPP PPDADPANEP PPPGPMPPAP RRGGGVGVGG GGTGVGGGDR DRDSGVVGAR PRASPPPQGP LPGPPGALHR WALAVPPGAV AGPRPQQASP PPCGGPGGPG GGPGDALGAA AAGVGAAGVV VGVGGAVGVG GCCSGPGHSK RRRQAPGVGA VGGGSPEREE VGAGYNSEDE YEAAAARIEA MDPATVEQQE HWFEKALRDK KGFIIKQMKE DGACLFRAVA DQVYGDQDMH EVVRKHCMDY LMKNADYFSN YVTEDFTTYI NRKRKNNCHG NHIEMQAMAE MYNRPVEVYQ YSTGTSAVEP INTFHGIHQN EDEPIRVSYH RNIHYNSVVN PNKATIGVGL GLPSFKPGFA EQSLMKNAIK TSEESWIEQQ MLEDKKRATD WEATNEAIEE QVARESYLQW LRDQEKQARQ VRGPSQPRKA SATCSSATAA ASSGLEEWTS RSPRQRSSAS SPEHPELHAE LGMKPPSPGT VLALAKPPSP CAPGTSSQFS AGADRATSPL VSLYPALECR ALIQQMSPSA FGLNDWDDDE ILASVLAVSQ QEYLDSMKKN KVHRDPPPDK S
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