E3 ubiquitin-protein transferase RMND5B (RMND5B)

About E3 ubiquitin-protein transferase RMND5B

E3 ubiquitin-protein transferase RMND5B (RMND5B) is a protein from Homo sapiens identified by UniProt accession Q96G75, 393 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	E3 ubiquitin-protein transferase RMND5B
UniProt accession	Q96G75
Gene	RMND5B
Organism	Homo sapiens
Length	393 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

dyskeratosis congenita · score 0.48
esophageal squamous cell carcinoma · score 0.03
neoplasm · score 0.01
systemic juvenile idiopathic arthritis · score 0.01
oral squamous cell carcinoma · score 0.01
dysplasia · score 0.01
calf circumference measurement · score 0.00
colorectal adenocarcinoma · score 0.00
cancer · score 0.00
esophageal adenocarcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96G75-F1	alphafold	PREDICTED	90.46	—

Amino-acid sequence (393 residues)

MEQCACVERE LDKVLQKFLT YGQHCERSLE ELLHYVGQLR AELASAALQG TPLSATLSLV MSQCCRKIKD TVQKLASDHK DIHSSVSRVG KAIDRNFDSE ICGVVSDAVW DAREQQQQIL QMAIVEHLYQ QGMLSVAEEL CQESTLNVDL DFKQPFLELN RILEALHEQD LGPALEWAVS HRQRLLELNS SLEFKLHRLH FIRLLAGGPA KQLEALSYAR HFQPFARLHQ REIQVMMGSL VYLRLGLEKS PYCHLLDSSH WAEICETFTR DACSLLGLSV ESPLSVSFAS GCVALPVLMN IKAVIEQRQC TGVWNHKDEL PIEIELGMKC WYHSVFACPI LRQQTSDSNP PIKLICGHVI SRDALNKLIN GGKLKCPYCP MEQNPADGKR IIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards