Seipin (BSCL2)

About Seipin

Seipin (BSCL2) is a protein from Homo sapiens identified by UniProt accession Q96G97, 398 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.

Target properties

Protein name	Seipin
UniProt accession	Q96G97
Gene	BSCL2
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (184)

Diseases linked to this target (Open Targets).

congenital generalized lipodystrophy type 2 · score 0.75
neuronopathy, distal hereditary motor, type 5C · score 0.74
severe neurodegenerative syndrome with lipodystrophy · score 0.74
hereditary spastic paraplegia 17 · score 0.74
Autosomal dominant spastic paraplegia type 17 · score 0.72
neuronopathy, distal hereditary motor, type 5A · score 0.56
Charcot-Marie-Tooth disease type 2 · score 0.55
genetic disorder · score 0.49
Distal hereditary motor neuropathy type 5 · score 0.46
hereditary spastic paraplegia · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96G97-F1	alphafold	PREDICTED	74.00	—

Amino-acid sequence (398 residues)

MVNDPPVPAL LWAQEVGQVL AGRARRLLLQ FGVLFCTILL LLWVSVFLYG SFYYSYMPTV SHLSPVHFYY RTDCDSSTTS LCSFPVANVS LTKGGRDRVL MYGQPYRVTL ELELPESPVN QDLGMFLVTI SCYTRGGRII STSSRSVMLH YRSDLLQMLD TLVFSSLLLF GFAEQKQLLE VELYADYREN SYVPTTGAII EIHSKRIQLY GAYLRIHAHF TGLRYLLYNF PMTCAFIGVA SNFTFLSVIV LFSYMQWVWG GIWPRHRFSL QVNIRKRDNS RKEVQRRISA HQPGPEGQEE STPQSDVTED GESPEDPSGT EGQLSEEEKP DQQPLSGEEE LEPEASDGSG SWEDAALLTE ANLPAPAPAS ASAPVLETLG SSEPAGGALR QRPTCSSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards