About Neurotrophin receptor-interacting factor homolog
Neurotrophin receptor-interacting factor homolog (ZNF274) is a protein
from Homo sapiens identified by UniProt accession
Q96GC6, 653 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Neurotrophin receptor-interacting factor homolog |
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| UniProt accession | Q96GC6 |
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| Gene | ZNF274 |
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| Organism | Homo sapiens |
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| Length | 653 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- medulloblastoma · score 0.19
- spermatogenic failure, X-linked, 2 · score 0.03
- Prader-Willi syndrome · score 0.02
- acute myeloid leukemia · score 0.01
- neoplasm · score 0.01
- cancer · score 0.01
- lung carcinoma · score 0.01
- lymph node metastatic carcinoma · score 0.01
- axial length measurement · score 0.00
- acute lymphoblastic leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96GC6-F1 | alphafold | PREDICTED | 59.18 | — |
Amino-acid sequence (653 residues)
MASRLPTAWS CEPVTFEDVT LGFTPEEWGL LDLKQKSLYR EVMLENYRNL VSVEHQLSKP DVVSQLEEAE DFWPVERGIP QDTIPEYPEL QLDPKLDPLP AESPLMNIEV VEVLTLNQEV AGPRNAQIQA LYAEDGSLSA DAPSEQVQQQ GKHPGDPEAA RQRFRQFRYK DMTGPREALD QLRELCHQWL QPKARSKEQI LELLVLEQFL GALPVKLRTW VESQHPENCQ EVVALVEGVT WMSEEEVLPA GQPAEGTTCC LEVTAQQEEK QEDAAICPVT VLPEEPVTFQ DVAVDFSREE WGLLGPTQRT EYRDVMLETF GHLVSVGWET TLENKELAPN SDIPEEEPAP SLKVQESSRD CALSSTLEDT LQGGVQEVQD TVLKQMESAQ EKDLPQKKHF DNRESQANSG ALDTNQVSLQ KIDNPESQAN SGALDTNQVL LHKIPPRKRL RKRDSQVKSM KHNSRVKIHQ KSCERQKAKE GNGCRKTFSR STKQITFIRI HKGSQVCRCS ECGKIFRNPR YFSVHKKIHT GERPYVCQDC GKGFVQSSSL TQHQRVHSGE RPFECQECGR TFNDRSAISQ HLRTHTGAKP YKCQDCGKAF RQSSHLIRHQ RTHTGERPYA CNKCGKAFTQ SSHLIGHQRT HNRTKRKKKQ PTS
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