About E3 ubiquitin-protein ligase RNF185
E3 ubiquitin-protein ligase RNF185 (RNF185) is a protein
from Homo sapiens identified by UniProt accession
Q96GF1, 192 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF185 |
|---|
| UniProt accession | Q96GF1 |
|---|
| Gene | RNF185 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 192 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- cystic fibrosis · score 0.47
- monocyte count · score 0.11
- lean body mass · score 0.08
- fat body mass · score 0.08
- myeloid white cell count · score 0.08
- neutrophil count · score 0.08
- eosinophil count · score 0.07
- Red cell distribution width · score 0.07
- BMI-adjusted waist-hip ratio · score 0.07
- BMI-adjusted waist circumference · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96GF1-F1 | alphafold | PREDICTED | 68.43 | — |
Amino-acid sequence (192 residues)
MASKGPSASA SPENSSAGGP SGSSNGAGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR GGFQGFGFGD GGFQMSFGIG AFPFGIFATA FNINDGRPPP AVPGTPQYVD EQFLSRLFLF VALVIMFWLL IA
Explore E3 ubiquitin-protein ligase RNF185 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets