About Long-chain-fatty-acid--CoA ligase ACSBG1
Long-chain-fatty-acid--CoA ligase ACSBG1 (ACSBG1) is a protein
from Homo sapiens identified by UniProt accession
Q96GR2, 724 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | Long-chain-fatty-acid--CoA ligase ACSBG1 |
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| UniProt accession | Q96GR2 |
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| Gene | ACSBG1 |
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| Organism | Homo sapiens |
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| Length | 724 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (101)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.39
- mean corpuscular hemoglobin concentration · score 0.38
- erythrocyte count · score 0.38
- platelet count · score 0.37
- Red cell distribution width · score 0.36
- hematocrit · score 0.36
- hemoglobin measurement · score 0.35
- mean reticulocyte volume · score 0.32
- mean corpuscular volume · score 0.32
- red blood cell density measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96GR2-F1 | alphafold | PREDICTED | 84.67 | — |
Amino-acid sequence (724 residues)
MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ PLSKESLNHA LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDLI ALGFKRQDKW EHISYSQYYL LARRAAKGFL KLGLKQAHSV AILGFNSPEW FFSAVGTVFA GGIVTGIYTT SSPEACQYIA YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP NKMANVYTME EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF AEPDALKGSL VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM LLWAMSVTLE QNLTCPGSDL KPFTTRLADY LVLAKVRQAL GFAKCQKNFY GAAPMMAETQ HFFLGLNIRL YAGYGLSETS GPHFMSSPYN YRLYSSGKLV PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI DEEGWLHTGD AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII EKKDEAVYQA IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM KLKRLTVLEK YKGIIDSFYQ EQKM
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