About Palmitoyltransferase ZDHHC12
Palmitoyltransferase ZDHHC12 (ZDHHC12) is a protein
from Homo sapiens identified by UniProt accession
Q96GR4, 267 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Palmitoyltransferase ZDHHC12 |
|---|
| UniProt accession | Q96GR4 |
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| Gene | ZDHHC12 |
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| Organism | Homo sapiens |
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| Length | 267 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- asthma · score 0.45
- Eczematoid dermatitis · score 0.38
- eosinophil count · score 0.31
- allergic rhinitis · score 0.30
- mean platelet volume · score 0.30
- seasonal allergic rhinitis · score 0.30
- Immature Reticulocyte Fraction Measurement · score 0.27
- atopic asthma · score 0.13
- waist-hip ratio · score 0.11
- triglyceride measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96GR4-F1 | alphafold | PREDICTED | 87.81 | — |
Amino-acid sequence (267 residues)
MAPWALLSPG VLVRTGHTVL TWGITLVLFL HDTELRQWEE QGELLLPLTF LLLVLGSLLL YLAVSLMDPG YVNVQPQPQE ELKEEQTAMV PPAIPLRRCR YCLVLQPLRA RHCRECRRCV RRYDHHCPWM ENCVGERNHP LFVVYLALQL VVLLWGLYLA WSGLRFFQPW GQWLRSSGLL FATFLLLSLF SLVASLLLVS HLYLVASNTT TWEFISSHRI AYLRQRPSNP FDRGLTRNLA HFFCGWPSGS WETLWAEEEE EGSSPAV
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