About Zinc finger protein 486
Zinc finger protein 486 (ZNF486) is a protein
from Homo sapiens identified by UniProt accession
Q96H40, 463 residues long.
MolForge cross-references it against 0 known binders and
7 disease associations.
Target properties
| Protein name | Zinc finger protein 486 |
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| UniProt accession | Q96H40 |
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| Gene | ZNF486 |
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| Organism | Homo sapiens |
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| Length | 463 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (7)
Diseases linked to this target (Open Targets).
- body height · score 0.22
- acute myeloid leukemia · score 0.18
- Down syndrome · score 0.05
- viral load · score 0.02
- endometrial carcinoma · score 0.00
- MALT lymphoma · score 0.00
- multiple myeloma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96H40-F1 | alphafold | PREDICTED | 68.21 | — |
Amino-acid sequence (463 residues)
MPGPLRSLEM ESLQFRDVAV EFSLEEWHCL DTAQQNLYRD VMLENYRHLV FLGIIVSKPD LITCLEQGIK PLTMKRHEMI AKPPVVCSHF AQDLWPEQSI KDSYQKVILR KFEKCGHGNL HFKKGCESVD ECKLHKRGYN GLNQCLTTTQ SKIFQCGKYV KVFHQFSNSK RHKRRHTEKK PLKYIEGDKA FNQSSTHTTH KKIDTGEKPY KCEECGKAFN RSSHLTTHKI THTREKPYKC EECGKVFKYF SSFTTHKKIH SGEKPYICEE CGKAFMYPYT LTTHKIIHTG EQPYKCKECD KAFNHPATLS SHKKIHTGEK PYTCDKCGKA FISSSILSKH EKIHTGEKPY KCEECGKAFT RSSHLTMHKI IHTGEKPYKC EECGKAFTWS AGLHKHRRTH TGEKPYKCEE CGKAYTTSSN LTEHKTTHTG EKPYKCKECG KAFNWSSDLN KHKRIHIGQK PRT
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