About PDZ and LIM domain protein 5
PDZ and LIM domain protein 5 (PDLIM5) is a protein
from Homo sapiens identified by UniProt accession
Q96HC4, 596 residues long.
MolForge cross-references it against 0 known binders and
246 disease associations.
Target properties
| Protein name | PDZ and LIM domain protein 5 |
|---|
| UniProt accession | Q96HC4 |
|---|
| Gene | PDLIM5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 596 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (246)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.45
- neurodegenerative disease · score 0.42
- pulse pressure measurement · score 0.36
- mean platelet volume · score 0.34
- creatinine measurement · score 0.34
- PR interval · score 0.32
- cystatin C measurement · score 0.30
- cancer · score 0.29
- electrocardiography · score 0.28
- uterine fibroid · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96HC4-F1 | alphafold | PREDICTED | 64.15 | — |
Amino-acid sequence (596 residues)
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF
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