Protein disulfide isomerase CRELD1 (CRELD1)

About Protein disulfide isomerase CRELD1

Protein disulfide isomerase CRELD1 (CRELD1) is a protein from Homo sapiens identified by UniProt accession Q96HD1, 420 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Protein disulfide isomerase CRELD1
UniProt accession	Q96HD1
Gene	CRELD1
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

Heterotaxia · score 0.51
visceral heterotaxy · score 0.51
congenital heart disease · score 0.42
ventricular septal defect 1 · score 0.42
body height · score 0.24
lean body mass · score 0.23
appendicular lean mass · score 0.22
genetic disorder · score 0.19
fat body mass · score 0.18
blood protein measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96HD1-F1	alphafold	PREDICTED	81.96	—

Amino-acid sequence (420 residues)

MAPWPPKGLV PAMLWGLSLF LNLPGPIWLQ PSPPPQSSPP PQPHPCHTCR GLVDSFNKGL ERTIRDNFGG GNTAWEEENL SKYKDSETRL VEVLEGVCSK SDFECHRLLE LSEELVESWW FHKQQEAPDL FQWLCSDSLK LCCPAGTFGP SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH CDCQAGYGGE ACGQCGLGYF EAERNASHLV CSACFGPCAR CSGPEESNCL QCKKGWALHH LKCVDIDECG TEGANCGADQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSPGYQQVG SKCLDVDECE TEVCPGENKQ CENTEGGYRC ICAEGYKQME GICVKEQIPE SAGFFSEMTE DELVVLQQMF FGIIICALAT LAAKGDLVFT AIFIGAVAAM TGYWLSERSD RVLEGFIKGR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards