ERO1-like protein alpha (ERO1A)

About ERO1-like protein alpha

ERO1-like protein alpha (ERO1A) is a protein from Homo sapiens identified by UniProt accession Q96HE7, 468 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	ERO1-like protein alpha
UniProt accession	Q96HE7
Gene	ERO1A
Organism	Homo sapiens
Length	468 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.37
urinary metabolite measurement · score 0.24
sitting height measurement · score 0.22
endometrial cancer · score 0.18
breast adenocarcinoma · score 0.18
low grade glioma · score 0.17
protein measurement · score 0.15
neoplasm · score 0.11
lung adenocarcinoma · score 0.10
non-small cell lung carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96HE7-F1	alphafold	PREDICTED	75.65	—

Amino-acid sequence (468 residues)

MGRGWGFLFG LLGAVWLLSS GHGEEQPPET AAQRCFCQVS GYLDDCTCDV ETIDRFNNYR LFPRLQKLLE SDYFRYYKVN LKRPCPFWND ISQCGRRDCA VKPCQSDEVP DGIKSASYKY SEEANNLIEE CEQAERLGAV DESLSEETQK AVLQWTKHDD SSDNFCEADD IQSPEAEYVD LLLNPERYTG YKGPDAWKIW NVIYEENCFK PQTIKRPLNP LASGQGTSEE NTFYSWLEGL CVEKRAFYRL ISGLHASINV HLSARYLLQE TWLEKKWGHN ITEFQQRFDG ILTEGEGPRR LKNLYFLYLI ELRALSKVLP FFERPDFQLF TGNKIQDEEN KMLLLEILHE IKSFPLHFDE NSFFAGDKKE AHKLKEDFRL HFRNISRIMD CVGCFKCRLW GKLQTQGLGT ALKILFSEKL IANMPESGPS YEFHLTRQEI VSLFNAFGRI STSVKELENF RNLLQNIH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards