Transmembrane protein 19 (TMEM19)

About Transmembrane protein 19

Transmembrane protein 19 (TMEM19) is a protein from Homo sapiens identified by UniProt accession Q96HH6, 336 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Transmembrane protein 19
UniProt accession	Q96HH6
Gene	TMEM19
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
cleft lip · score 0.29
Cleft palate · score 0.29
small intestine cancer · score 0.17
chronic kidney disease · score 0.01
non-alcoholic fatty liver disease · score 0.01
Alzheimer disease · score 0.00
invasive breast ductal carcinoma · score 0.00
breast cancer · score 0.00
non-alcoholic steatohepatitis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96HH6-F1	alphafold	PREDICTED	91.35	—

Amino-acid sequence (336 residues)

MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS PWRWLFSVVV PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL LMFFLSSSKL TKWKGEVKKR LDSEYKEGGQ RNWVQVFCNG AVPTELALLY MIENGPGEIP VDFSKQYSAS WMCLSLLAAL ACSAGDTWAS EVGPVLSKSS PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT QLIFVNDLDI SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards