GRAM domain-containing protein 2B (GRAMD2B)

About GRAM domain-containing protein 2B

GRAM domain-containing protein 2B (GRAMD2B) is a protein from Homo sapiens identified by UniProt accession Q96HH9, 432 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	GRAM domain-containing protein 2B
UniProt accession	Q96HH9
Gene	GRAMD2B
Organism	Homo sapiens
Length	432 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

diabetic nephropathy · score 0.27
type 2 diabetes mellitus · score 0.27
hematocrit · score 0.24
hemoglobin measurement · score 0.23
protein measurement · score 0.18
neurofibrillary tangles measurement · score 0.17
visceral adipose tissue measurement · score 0.16
body mass index · score 0.16
hypopituitarism · score 0.16
cognitive decline measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96HH9-F1	alphafold	PREDICTED	63.17	—

Amino-acid sequence (432 residues)

MTELQQDVED TKPAKVLGKR ESKLGSAHSE AENGVEEKKK ACRSPTAQSP TPSVEADSPD QKKIISLWSK SSFDGASLAS DKNDCKTESK NDPKTERKKS SSSSQYKANM HFHKLFLSVP TEEPLKQSFT CALQKEILYQ GKLFVSENWI CFHSKVFGKD TKISIPAFSV TLIKKTKTAL LVPNALIIAT VTDRYIFVSL LSRDSTYKLL KSVCGHLENT SVGNSPNPSS AENSFRADRP SSLPLDFNDE FSDLDGVVQQ RRQDMEGYSS SGSQTPESEN SRDFHATESQ TVLNVSKGEA KPTRADAHVN RVPEGKAKSL PVQGLSETVG ILHKVKSQKC PMLHHILIFY AIVVCALIIS TFYMRYRINT LEEQLGLLTS IVDTHNTEQA APSGLRSQVQ FNVEVLCQEL TANIVKLEKI QNNLQKLLEN GD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards