PC-esterase domain-containing protein 1B (PCED1B)

About PC-esterase domain-containing protein 1B

PC-esterase domain-containing protein 1B (PCED1B) is a protein from Homo sapiens identified by UniProt accession Q96HM7, 432 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	PC-esterase domain-containing protein 1B
UniProt accession	Q96HM7
Gene	PCED1B
Organism	Homo sapiens
Length	432 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

chemotherapy-induced cytotoxicity measurement · score 0.34
PHF-tau measurement · score 0.32
neurodegenerative disease · score 0.28
omega-3 polyunsaturated fatty acid measurement · score 0.25
sex interaction measurement · score 0.25
inflammatory bowel disease · score 0.12
gonorrhea · score 0.08
nonpapillary renal cell carcinoma · score 0.07
colorectal adenocarcinoma · score 0.07
skin pigmentation · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96HM7-F1	alphafold	PREDICTED	71.88	—

Amino-acid sequence (432 residues)

MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA RGELNFEQDE LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD YLQTILKELQ SGEHAPDLVI MNSCLWDISR YGPNSWRSYL ENLENLFQCL GQVLPESCLL VWNTAMPVGE EVTGGFLPPK LRRQKATFLK NEVVKANFHS ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL SQLLLAHVAD AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS DQFYCHSDVP SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF GRYRPRGPYT PWGQRPRPSK RRAPANPEPR PQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards