About Transmembrane protein 176A
Transmembrane protein 176A (TMEM176A) is a protein
from Homo sapiens identified by UniProt accession
Q96HP8, 235 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | Transmembrane protein 176A |
|---|
| UniProt accession | Q96HP8 |
|---|
| Gene | TMEM176A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 235 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (101)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.32
- neurodegenerative disease · score 0.31
- serum albumin measurement · score 0.30
- calcium measurement · score 0.29
- hemoglobin measurement · score 0.29
- alkaline phosphatase measurement · score 0.27
- appendicular lean mass · score 0.25
- testosterone measurement · score 0.25
- diastolic blood pressure · score 0.24
- hematocrit · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96HP8-F1 | alphafold | PREDICTED | 74.07 | — |
Amino-acid sequence (235 residues)
MGTADSDEMA PEAPQHTHID VHIHQESALA KLLLTCCSAL RPRATQARGS SRLLVASWVM QIVLGILSAV LGGFFYIRDY TLLVTSGAAI WTGAVAVLAG AAAFIYEKRG GTYWALLRTL LTLAAFSTAI AALKLWNEDF RYGYSYYNSA CRISSSSDWN TPAPTQSPEE VRRLHLCTSF MDMLKALFRT LQAMLLGVWI LLLLASLTPL WLYCWRMFPT KGKRDQKEML EVSGI
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