About Mediator of RNA polymerase II transcription subunit 30
Mediator of RNA polymerase II transcription subunit 30 (MED30) is a protein
from Homo sapiens identified by UniProt accession
Q96HR3, 178 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 30 |
|---|
| UniProt accession | Q96HR3 |
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| Gene | MED30 |
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| Organism | Homo sapiens |
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| Length | 178 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (120)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- fasting blood glucose measurement · score 0.21
- adolescent idiopathic scoliosis · score 0.19
- bone measurement · score 0.12
- smoking status measurement · score 0.08
- systolic blood pressure · score 0.08
- vestibular neuronitis · score 0.08
- leprosy · score 0.06
- hypertrophic cardiomyopathy · score 0.06
- left ventricular noncompaction · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96HR3-F1 | alphafold | PREDICTED | 77.70 | — |
Amino-acid sequence (178 residues)
MSTPPLAASG MAPGPFAGPQ AQQAAREVNT ASLCRIGQET VQDIVYRTME IFQLLRNMQL PNGVTYHTGT YQDRLTKLQD NLRQLSVLFR KLRLVYDKCN ENCGGMDPIP VEQLIPYVEE DGSKNDDRAG PPRFASEERR EIAEVNKKLK QKNQQLKQIM DQLRNLIWDI NAMLAMRN
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