About Serine/threonine-protein phosphatase PGAM5, mitochondrial
Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5) is a protein
from Homo sapiens identified by UniProt accession
Q96HS1, 289 residues long.
MolForge cross-references it against 0 known binders and
162 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase PGAM5, mitochondrial |
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| UniProt accession | Q96HS1 |
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| Gene | PGAM5 |
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| Organism | Homo sapiens |
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| Length | 289 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (162)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.31
- mean corpuscular hemoglobin concentration · score 0.30
- mean corpuscular volume · score 0.30
- mean reticulocyte volume · score 0.24
- reticulocyte measurement · score 0.21
- lymphocyte count · score 0.19
- Immature Reticulocyte Fraction Measurement · score 0.18
- Red cell distribution width · score 0.18
- hepatocellular carcinoma · score 0.10
- microphthalmia with limb anomalies · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96HS1-F1 | alphafold | PREDICTED | 84.63 | — |
Amino-acid sequence (289 residues)
MAFRQALQLA ACGLAGGSAA VLFSAVAVGK PRAGGDAEPR PAEPPAWAGG ARPGPGVWDP NWDRREPLSL INVRKRNVES GEEELASKLD HYKAKATRHI FLIRHSQYHV DGSLEKDRTL TPLGREQAEL TGLRLASLGL KFNKIVHSSM TRAIETTDII SRHLPGVCKV STDLLREGAP IEPDPPVSHW KPEAVQYYED GARIEAAFRN YIHRADARQE EDSYEIFICH ANVIRYIVCR ALQFPPEGWL RLSLNNGSIT HLVIRPNGRV ALRTLGDTGF MPPDKITRS
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