About Protein phosphatase 1 regulatory subunit 16A
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) is a protein
from Homo sapiens identified by UniProt accession
Q96I34, 528 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 16A |
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| UniProt accession | Q96I34 |
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| Gene | PPP1R16A |
|---|
| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- mean corpuscular hemoglobin concentration · score 0.28
- self reported educational attainment · score 0.22
- mathematical ability · score 0.21
- holoprosencephaly · score 0.18
- blood metabolite measurement · score 0.18
- cognitive function measurement · score 0.17
- age at first birth measurement · score 0.16
- intelligence · score 0.16
- testosterone measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96I34-F1 | alphafold | PREDICTED | 72.66 | — |
Amino-acid sequence (528 residues)
MAEHLELLAE MPMVGRMSTQ ERLKHAQKRR AQQVKMWAQA EKEAQGKKGP GERPRKEAAS QGLLKQVLFP PSVVLLEAAA RNDLEEVRQF LGSGVSPDLA NEDGLTALHQ CCIDDFREMV QQLLEAGANI NACDSECWTP LHAAATCGHL HLVELLIASG ANLLAVNTDG NMPYDLCDDE QTLDCLETAM ADRGITQDSI EAARAVPELR MLDDIRSRLQ AGADLHAPLD HGATLLHVAA ANGFSEAAAL LLEHRASLSA KDQDGWEPLH AAAYWGQVPL VELLVAHGAD LNAKSLMDET PLDVCGDEEV RAKLLELKHK HDALLRAQSR QRSLLRRRTS SAGSRGKVVR RVSLTQRTDL YRKQHAQEAI VWQQPPPTSP EPPEDNDDRQ TGAELRPPPP EEDNPEVVRP HNGRVGGSPV RHLYSKRLDR SVSYQLSPLD STTPHTLVHD KAHHTLADLK RQRAAAKLQR PPPEGPESPE TAEPGLPGDT VTPQPDCGFR AGGDPPLLKL TAPAVEAPVE RRPCCLLM
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