About G patch domain-containing protein 3
G patch domain-containing protein 3 (GPATCH3) is a protein
from Homo sapiens identified by UniProt accession
Q96I76, 525 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | G patch domain-containing protein 3 |
|---|
| UniProt accession | Q96I76 |
|---|
| Gene | GPATCH3 |
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| Organism | Homo sapiens |
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| Length | 525 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- urate measurement · score 0.05
- glomerular filtration rate · score 0.05
- serum alanine aminotransferase measurement · score 0.05
- high density lipoprotein cholesterol measurement · score 0.05
- triglyceride measurement · score 0.04
- low density lipoprotein cholesterol measurement · score 0.04
- monocyte count · score 0.04
- apolipoprotein B measurement · score 0.04
- apolipoprotein A 1 measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96I76-F1 | alphafold | PREDICTED | 67.06 | — |
Amino-acid sequence (525 residues)
MAVPGEAEEE ATVYLVVSGI PSVLRSAHLR SYFSQFREER GGGFLCFHYR HRPERAPPQA APNSALIPTD PAAEGQLLSQ TSATDVRPLS TRDSTPIQTR TCCCVISVRG LAQAQRLIRM YSGRRWLDSH GTWLPGRCLI RRLRLPTEAS GLGSFPFKTR KELQSWKAEN EAFTLADLKQ LPELNPPVLM PRGNVGTPLR VFLELIRACR LPPRIITQLQ LQFPKTGSSR RYGNVPFEYE DSETVEQEEL VYTAEGEEIP QGTYLADIPA SPCGEPEEEV GKEEEEESHS DEDDDRGEEW ERHEALHEDV TGQERTTEQL FEEEIELKWE KGGSGLVFYT DAQFWQEEEG DFDEQTADDW DVDMSVYYDR DGGDKDARDS VQMRLEQRLR DGQEDGSVIE RQVGTFERHT KGIGRKVMER QGWAEGQGLG CRCSGVPEAL DSDGQHPRCK RGLGYHGEKL QPFGQLKRPR RNGLGLISTI YDEPLPQDQT ESLLRRQPPT SMKFRTDMAF VRGSSCASDS PSLPD
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