About Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2) is a protein
from Homo sapiens identified by UniProt accession
Q96I99, 432 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial |
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| UniProt accession | Q96I99 |
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| Gene | SUCLG2 |
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| Organism | Homo sapiens |
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| Length | 432 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (88)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.31
- mean corpuscular volume · score 0.31
- body height · score 0.31
- forced expiratory volume · score 0.28
- mean corpuscular hemoglobin · score 0.27
- self reported educational attainment · score 0.27
- mean corpuscular hemoglobin concentration · score 0.27
- platelet count · score 0.26
- sitting height measurement · score 0.21
- beta-amyloid 1-42 measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96I99-F1 | alphafold | PREDICTED | 89.23 | — |
Amino-acid sequence (432 residues)
MASPVAAQAG KLLRALALRP RFLAAGSQAV QLTSRRWLNL QEYQSKKLMS DNGVRVQRFF VADTANEALE AAKRLNAKEI VLKAQILAGG RGKGVFNSGL KGGVHLTKDP NVVGQLAKQM IGYNLATKQT PKEGVKVNKV MVAEALDISR ETYLAILMDR SCNGPVLVGS PQGGVDIEEV AASNPELIFK EQIDIFEGIK DSQAQRMAEN LGFVGPLKSQ AADQITKLYN LFLKIDATQV EVNPFGETPE GQVVCFDAKI NFDDNAEFRQ KDIFAMDDKS ENEPIENEAA KYDLKYIGLD GNIACFVNGA GLAMATCDII FLNGGKPANF LDLGGGVKEA QVYQAFKLLT ADPKVEAILV NIFGGIVNCA IIANGITKAC RELELKVPLV VRLEGTNVQE AQKILNNSGL PITSAIDLED AAKKAVASVA KK
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