About RNA exonuclease 5
RNA exonuclease 5 (REXO5) is a protein
from Homo sapiens identified by UniProt accession
Q96IC2, 774 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | RNA exonuclease 5 |
|---|
| UniProt accession | Q96IC2 |
|---|
| Gene | REXO5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 774 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (14)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.13
- mean corpuscular volume · score 0.11
- systolic blood pressure · score 0.08
- body height · score 0.08
- eosinophil count · score 0.06
- appendicular lean mass · score 0.05
- erythrocyte count · score 0.04
- eosinophil percentage of leukocytes · score 0.04
- fat body mass · score 0.03
- lean body mass · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96IC2-F1 | alphafold | PREDICTED | 77.96 | — |
Amino-acid sequence (774 residues)
MEPEREGTER HPRKVRESRQ APNKLVGAAE AMKAGWDLEE SQPEAKKARL STILFTDNCE VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF VLQGMSQLHF YRFYLEFGCL RKAFRHKFRL PPPSSDFLAD VVGLQTEQRA GDLPKTMEGP LPSNAKAAIN LQDDPIIQKY GSKKVGLTRC LLTKEEMRTF HFPLQGFPDC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK GRELTRISLV AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKVI LGKDIQCPDR LGHDATEDAR TILELARYFL KHGPKKIAEL NLEALANHQE IQAAGQEPKN TAEVLQHPNT SVLECLDSVG QKLLFLTRET DAGELPSSRN CQTIKCLSNK EVLEQARVEI PLFPFSIVQF SFKAFSPVLT EEMNKRMRIK WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET RQPHLCIQYE VLEAAQLAIE SLDGILVDGI CIKVQRPVTE LTLDCDTLVN ELEGDSENQG SIYLSGVSET FKEQLLQEPR LFLGLEAVIL PKDLKSGKQK KYCFLKFKSF GSAQQALNIL TGKDWKLKGR HALTPRHLHA WLRGLPPEST RLPGLRVVPP PFEQEALQTL KLDHPKIAAW RWSRKIGKLY NSLCPGTLCL ILLPGTKSTH GSLSGLGLMG IKEEEESAGP GLCS
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