Immunoglobulin superfamily member 21 (IGSF21)

About Immunoglobulin superfamily member 21

Immunoglobulin superfamily member 21 (IGSF21) is a protein from Homo sapiens identified by UniProt accession Q96ID5, 467 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Immunoglobulin superfamily member 21
UniProt accession	Q96ID5
Gene	IGSF21
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

protein measurement · score 0.43
smoking status measurement · score 0.37
self reported educational attainment · score 0.36
neurofibrillary tangles measurement · score 0.32
viral load · score 0.31
smoking cessation · score 0.30
antisocial behaviour measurement · score 0.30
attention deficit hyperactivity disorder · score 0.30
smoking initiation · score 0.30
substance abuse · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96ID5-F1	alphafold	PREDICTED	76.59	—

Amino-acid sequence (467 residues)

MRTAPSLRRC VCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT DGRMREIVWY RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST VRLPEVRISD NGPYECHVGI YDRATREKVV LASGNIFLNV MAPPTSIEVV AADTPAPFSR YQAQNFTLVC IVSGGKPAPM VYFKRDGEPI DAVPLSEPPA ASSGPLQDSR PFRSLLHRDL DDTKMQKSLS LLDAENRGGR PYTERPSRGL TPDPNILLQP TTENIPETVV SREFPRWVHS AEPTYFLRHS RTPSSDGTVE VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIVMTP SRARVGDTVR ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE RVPAELNGSM YRCTAQNPLG STDTHTRLIV FENPNIPRGT EDSNGSIGPT GARLTLVLAL TVILELT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards