F-box/LRR-repeat protein 20 (FBXL20)

About F-box/LRR-repeat protein 20

F-box/LRR-repeat protein 20 (FBXL20) is a protein from Homo sapiens identified by UniProt accession Q96IG2, 436 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.

Target properties

Protein name	F-box/LRR-repeat protein 20
UniProt accession	Q96IG2
Gene	FBXL20
Organism	Homo sapiens
Length	436 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (118)

Diseases linked to this target (Open Targets).

creatinine measurement · score 0.24
blood phosphate measurement · score 0.23
Red cell distribution width · score 0.23
mean corpuscular volume · score 0.22
mean platelet volume · score 0.22
vital capacity · score 0.22
platelet count · score 0.20
mean corpuscular hemoglobin concentration · score 0.19
serum urea measurement · score 0.19
Immature Reticulocyte Fraction Measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96IG2-F1	alphafold	PREDICTED	90.87	—

Amino-acid sequence (436 residues)

MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ VSRAWNVLAL DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG CLGVGDNALR TFAQNCRNIE VLNLNGCTKT TDATCTSLSK FCSKLRHLDL ASCTSITNMS LKALSEGCPL LEQLNISWCD QVTKDGIQAL VRGCGGLKAL FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI TICRGCHKLQ SLCASGCSNI TDAILNALGQ NCPRLRILEV ARCSQLTDVG FTTLARNCHE LEKMDLEECV QITDSTLIQL SIHCPRLQVL SLSHCELITD DGIRHLGNGA CAHDQLEVIE LDNCPLITDA SLEHLKSCHS LERIELYDCQ QITRAGIKRL RTHLPNIKVH AYFAPVTPPP SVGGSRQRFC RCCIIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards