Cytochrome c oxidase assembly factor 8 (COA8)

About Cytochrome c oxidase assembly factor 8

Cytochrome c oxidase assembly factor 8 (COA8) is a protein from Homo sapiens identified by UniProt accession Q96IL0, 206 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Cytochrome c oxidase assembly factor 8
UniProt accession	Q96IL0
Gene	COA8
Organism	Homo sapiens
Length	206 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

mitochondrial complex 4 deficiency, nuclear type 17 · score 0.68
cytochrome-c oxidase deficiency disease · score 0.46
mitochondrial complex IV deficiency, nuclear type 22 · score 0.43
leigh syndrome due to mitochondrial complex iv deficiency · score 0.43
blood protein measurement · score 0.40
mitochondrial disease · score 0.37
schizophrenia · score 0.33
self reported educational attainment · score 0.28
bipolar disorder · score 0.27
unipolar depression · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96IL0-F1	alphafold	PREDICTED	79.57	—

Amino-acid sequence (206 residues)

MLPCAAGARG RGAMVVLRAG KKTFLPPLCR AFACRGCQLA PERGAERRDT APSGVSRFCP PRKSCHDWIG PPDKYSNLRP VHFYIPENES PLEQKLRKLR QETQEWNQQF WANQNLTFSK EKEEFIHSRL KTKGLGLRTE SGQKATLNAE EMADFYKEFL SKNFQKHMYY NRDWYKRNFA ITFFMGKVAL ERIWNKLKQK QKKRSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards