About 4-hydroxyphenylpyruvate dioxygenase-like protein
4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) is a protein
from Homo sapiens identified by UniProt accession
Q96IR7, 371 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | 4-hydroxyphenylpyruvate dioxygenase-like protein |
|---|
| UniProt accession | Q96IR7 |
|---|
| Gene | HPDL |
|---|
| Organism | Homo sapiens |
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| Length | 371 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities · score 0.80
- spastic paraplegia 83, autosomal recessive · score 0.69
- Inherited congenital spastic tetraplegia · score 0.54
- genetic disorder · score 0.52
- spastic ataxia · score 0.43
- Spastic paraplegia · score 0.42
- complex neurodevelopmental disorder · score 0.37
- Leigh syndrome · score 0.19
- mean platelet volume · score 0.07
- Familial exudative vitreoretinopathy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96IR7-F1 | alphafold | PREDICTED | 91.14 | — |
Amino-acid sequence (371 residues)
MAAPALRLCH IAFHVPAGQP LARNLQRLFG FQPLASREVD GWRQLALRSG DAVFLVNEGA GSGEPLYGLD PRHAVPSATN LCFDVADAGA ATRELAALGC SVPVPPVRVR DAQGAATYAV VSSPAGILSL TLLERAGYRG PFLPGFRPVS SAPGPGWVSR VDHLTLACTP GSSPTLLRWF HDCLGFCHLP LSPGEDPELG LEMTAGFGLG GLRLTALQAQ PGSIVPTLVL AESLPGATTR QDQVEQFLAR HKGPGLQHVG LYTPNIVEAT EGVATAGGQF LAPPGAYYQQ PGKERQIRAA GHEPHLLARQ GILLDGDKGK FLLQVFTKSL FTEDTFFLEL IQRQGATGFG QGNIRALWQS VQEQSARSQE A
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