About Retina and anterior neural fold homeobox protein 2
Retina and anterior neural fold homeobox protein 2 (RAX2) is a protein
from Homo sapiens identified by UniProt accession
Q96IS3, 184 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Retina and anterior neural fold homeobox protein 2 |
|---|
| UniProt accession | Q96IS3 |
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| Gene | RAX2 |
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| Organism | Homo sapiens |
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| Length | 184 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- Cone rod dystrophy · score 0.68
- age-related macular degeneration · score 0.55
- Retinal dystrophy · score 0.39
- retinitis pigmentosa · score 0.37
- macular degeneration · score 0.16
- glioblastoma · score 0.04
- alkaline phosphatase measurement · score 0.03
- respiratory distress syndrome in premature infants · score 0.02
- serum alanine aminotransferase measurement · score 0.02
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96IS3-F1 | alphafold | PREDICTED | 69.72 | — |
Amino-acid sequence (184 residues)
MFLSPGEGPA TEGGGLGPGE EAPKKKHRRN RTTFTTYQLH QLERAFEASH YPDVYSREEL AAKVHLPEVR VQVWFQNRRA KWRRQERLES GSGAVAAPRL PEAPALPFAR PPAMSLPLEP WLGPGPPAVP GLPRLLGPGP GLQASFGPHA FAPTFADGFA LEEASLRLLA KEHAQALDRA WPPA
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