Zinc finger BED domain-containing protein 3 (ZBED3)

About Zinc finger BED domain-containing protein 3

Zinc finger BED domain-containing protein 3 (ZBED3) is a protein from Homo sapiens identified by UniProt accession Q96IU2, 234 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Zinc finger BED domain-containing protein 3
UniProt accession	Q96IU2
Gene	ZBED3
Organism	Homo sapiens
Length	234 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.40
BMI-adjusted waist-hip ratio · score 0.40
glucose measurement · score 0.34
diabetes mellitus · score 0.34
waist-hip ratio · score 0.32
HbA1c measurement · score 0.28
hemoglobin A1 measurement · score 0.25
Varicose veins · score 0.23
high density lipoprotein cholesterol measurement · score 0.22
testosterone measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96IU2-F1	alphafold	PREDICTED	73.41	—

Amino-acid sequence (234 residues)

MRSGEPACTM DQARGLDDAA ARGGQCPGLG PAPTPTPPGR LGAPYSEAWG YFHLAPGRPG HPSGHWATCR LCGEQVGRGP GFHAGTSALW RHLRSAHRRE LESSGAGSSP PAAPCPPPPG PAAAPEGDWA RLLEQMGALA VRGSRREREL ERRELAVEQG ERALERRRRA LQEEERAAAQ ARRELQAERE ALQARLRDVS RREGALGWAP AAPPPLKDDP EGDRDGCVIT KVLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards