ATP synthase F(0) complex subunit k, mitochondrial…

About ATP synthase F(0) complex subunit k, mitochondrial

ATP synthase F(0) complex subunit k, mitochondrial (ATP5MK) is a protein from Homo sapiens identified by UniProt accession Q96IX5, 58 residues long. MolForge cross-references it against 0 known binders and 382 disease associations.

Target properties

Protein name	ATP synthase F(0) complex subunit k, mitochondrial
UniProt accession	Q96IX5
Gene	ATP5MK
Organism	Homo sapiens
Length	58 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (382)

Diseases linked to this target (Open Targets).

mitochondrial complex 5 (ATP synthase) deficiency, nuclear type 6 · score 0.50
mitochondrial complex V deficiency, nuclear type 6 · score 0.37
Isolated ATP synthase deficiency · score 0.37
Leigh syndrome · score 0.19
malaria · score 0.09
hepatocellular carcinoma · score 0.09
Cirrhosis · score 0.08
melanoma · score 0.08
breast cancer · score 0.08
insulin resistance · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96IX5-F1	alphafold	PREDICTED	76.67	—

Amino-acid sequence (58 residues)

MAGPESDAQY QFTGIKKYFN SYTLTGRMNC VLATYGSIAL IVLYFKLRSK KTPAVKAT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

ATP synthase F(0) complex subunit k, mitochondrial (ATP5MK)